Protein Structure Prediction Center
Welcome to the Protein Structure Prediction Center!

Our goal is to help advance the methods of identifying protein structure from sequence. The Center has been organized to provide the means of objective testing of these methods via the process of blind prediction. The Critical Assessment of protein Structure Prediction (CASP) experiments aim at establishing the current state of the art in protein structure prediction, identifying what progress has been made, and highlighting where future effort may be most productively focused.

There have been ten previous CASP experiments. The eleventh experiment will start in May 2014. Description of these experiments and the full data (targets, predictions, interactive tables with numerical evaluation results, dynamic graphs and prediction visualization tools) can be accessed following the links:

CASP1 (1994) | CASP2 (1996) | CASP3 (1998) | CASP4 (2000) | CASP5 (2002) | CASP6 (2004) | CASP7 (2006) | CASP8 (2008) | CASP9 (2010) | CASP10 (2012) | CASP11 (2014)

Raw data for the experiments held so far are archived and stored in our data archive.

In November 2011 we have opened a new rolling CASP experiment for all-year-round testing of ab initio modeling methods:

CASP ROLL 


Details of the experiments have been published in a scientific journal Proteins: Structure, Function and Bioinformatics. CASP proceedings include papers describing the structure and conduct of the experiments, the numerical evaluation measures, reports from the assessment teams highlighting state of the art in different prediction categories, methods from some of the most successful prediction teams, and progress in various aspects of the modeling.
Prediction methods are assessed on the basis of the analysis of a large number of blind predictions of protein structure. Summary of numerical evaluation of the methods tested in the latest CASP experiment can be found on this web page. The main numerical measures used in evaluations are described in the papers [1] , [2] . The latter paper also contains explanations of data handling procedures and guidelines for navigating the data presented on this website.

Some of the best performing methods are implemented as fully automated servers and therefore can be used by public for protein structure modeling.


To proceed to the pages related to the latest CASP experiments click on the logo below:

CASP11 Home   FORCASP Forum

Discussion Forum



Prediction
of docking interactions
Automated benchmarking
of prediction servers
Assessment of automated
structure prediction
Automatic evaluation
of prediction servers
Last targets in contact-assisted category
Dear CASPers, 1. This week we are releasing the last 6 targets in contact-assisted categories Ts and Tc. Three of these targets (Tc826, Tc827 and Ts812) will be released today after closing the cor ...
End of CASP11 regular prediction season
Dear CASP predictors, Yesterday we closed the last three regular CASP11 targets. All in all, we released 100 targets including 55 all-group targets, and collected over 55,000 predictions. Thanks a ...
Updated file for Tx812
Dear Tx predictors, Please update the input file for target Tx812. The originally posted file was fine except it included a few contact pairs to non-existing residues 250-254 (should be 200-204 ins ...
Protein Structure Prediction Center
Sponsored by the US National Institute of General Medical Sciences (NIH/NIGMS)
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