Protein Structure Prediction Center
Welcome to the Protein Structure Prediction Center!

Our goal is to help advance the methods of identifying protein structure from sequence. The Center has been organized to provide the means of objective testing of these methods via the process of blind prediction. The Critical Assessment of protein Structure Prediction (CASP) experiments aim at establishing the current state of the art in protein structure prediction, identifying what progress has been made, and highlighting where future effort may be most productively focused.

There have been eleven previous CASP experiments. The twelfth experiment is planned to start in May 2016. Description of these experiments and the full data (targets, predictions, interactive tables with numerical evaluation results, dynamic graphs and prediction visualization tools) can be accessed following the links:

CASP1 (1994) | CASP2 (1996) | CASP3 (1998) | CASP4 (2000) | CASP5 (2002) | CASP6 (2004) | CASP7 (2006) | CASP8 (2008) | CASP9 (2010) | CASP10 (2012) | CASP11 (2014) | CASP12 (2016)

Raw data for the experiments held so far are archived and stored in our data archive.

In November 2011 we have opened a new rolling CASP experiment for all-year-round testing of ab initio modeling methods:

CASP ROLL 


Details of the experiments have been published in a scientific journal Proteins: Structure, Function and Bioinformatics. CASP proceedings include papers describing the structure and conduct of the experiments, the numerical evaluation measures, reports from the assessment teams highlighting state of the art in different prediction categories, methods from some of the most successful prediction teams, and progress in various aspects of the modeling.
Prediction methods are assessed on the basis of the analysis of a large number of blind predictions of protein structure. Summary of numerical evaluation of the methods tested in the latest CASP experiment can be found on this web page. The main numerical measures used in evaluations are described in the papers [1] , [2] . The latter paper also contains explanations of data handling procedures and guidelines for navigating the data presented on this website.

Some of the best performing methods are implemented as fully automated servers and therefore can be used by public for protein structure modeling.


To proceed to the pages related to the latest CASP experiments click on the logo below:

CASP12 Home   FORCASP Forum

Discussion Forum



Prediction
of docking interactions
Automated benchmarking
of prediction servers
Assessment of automated
structure prediction
Automatic evaluation
of prediction servers
End of CASP12 regular prediction season
*** Regular targets Today we closed for prediction the last regular CASP12 target - T0946. All in all, we released 82 targets including 56 all-group targets, and collected over 53,000 predictions. Th ...
Penultimate week of target release
=== Refinement targets This week we are releasing 5 more refinement targets: one on Monday and Tuesday, two on Wednesday and one more on Friday. Another five targets are expected for the last week. ...
Two more regular targets; IA prediction only on your own quaternary models or from sequence
=== Two new regular targets (well, actually one) Target T0947 was received just yesterday and we will have it in CASP12 as both - regular and SAXS-assisted target. Target T0948 is a re-release of t ...
Protein Structure Prediction Center
Sponsored by the US National Institute of General Medical Sciences (NIH/NIGMS)
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